SLC22A2

Protein name: OCT2 Aliases: N/D Substrates: organic cations Transport type: Facilitated transporter Tissue and cellular expression: kidney, small intestine, lung, placenta, thymus, brain (neurons, blood-brain barrier), inner ear Subcellular expression: basolateral membrane of proximal tubules (kidney) Disease: cytotoxicity of cisplatin, oxaliplatin and picoplatin Locus: 6q26 Sequence ID: NP_003049.2, NM_003058.3 Gene ID: 6582 Splice variants: OCT2-A from kidney with uptake in vitro

S22A2_HUMAN (UniProt)

Gene names: SLC22A2, OCT2
Protein names and data: S22A2_HUMAN, Full=Solute carrier family 22 member 2, Full=Organic cation transporter 2;Short=hOCT2; Length: 555 a.a., Mass: 62581 Da,
fasta formatted sequence
Function: Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity
Cellular location: Membrane; Multi-pass membrane protein (Potential)
Tissue specificity: Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma

Database cross-references

UniProt: O15244
NextBio: 25613
OMIM: 602608
Ensembl: ENST00000366953
GeneCard: GC06M160173
PharmGenUCSF: SLC22A2
Guide to Pharmacology: SLC22A2 (1020)
Organic cation transporters (OCT) (1020)
HGNC: HGNC:10966

Genetic variants

See also Ensembl:ENST00000366953