SLC22A17
Protein name: BOIT Aliases: BOCT, NGALR Substrates: not determined Transport type: Orphan transporter Tissue and cellular expression: brain Subcellular expression: N/D Disease: N/D Locus: 14q11.2 Sequence ID: NP_057693.3, NM_016609.3 NP_065105.2, NM_020372.2 Gene ID: 51310 Splice variants: 2 splice variantsS22AH_HUMAN (UniProt)
Gene names: SLC22A17, BOCT, BOITProtein names and data: S22AH_HUMAN, Full=Solute carrier family 22 member 17, Full=24p3 receptor;Short=24p3R;Full=Brain-type organic cation transporter;Full=Lipocalin-2 receptor;Full=Neutrophil gelatinase-associated lipocalin receptor;Short=NgalR; Length: 538 a.a., Mass: 57686 Da,
fasta formatted sequence
Function: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity)
Cellular location: Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Note=Upon LCN2- binding, it is internalized
Tissue specificity: Expressed in brain
Database cross-references
UniProt: Q8WUG5NextBio: 54641
OMIM: 611461
Ensembl: ENST00000397267
GeneCard: GC14M023346
TCDB: 2.A.1.19.8
PharmGenUCSF: SLC22A17
Guide to Pharmacology: SLC22A17 (1035)
Orphan or poorly characterized SLC22 family members (1035)
HGNC: HGNC:23095