SLC22A16

Protein name: 39726 Aliases: FLIPT2, CT2 Substrates: L-carnitine, noncharged compounds Transport type: Facilitated transporter Tissue and cellular expression: testis (Sertoli cells and epididymal duct cells), bone marrow, leukocytes, kidney Subcellular expression: N/D Disease: bipolar l disorder Locus: 6q21-q22.1 Sequence ID: NP_149116.2, NM_033125.3 Gene ID: 85413 Splice variants: N/D

S22AG_HUMAN (UniProt)

Gene names: SLC22A16, OCT6
Protein names and data: S22AG_HUMAN, Full=Solute carrier family 22 member 16, Full=Carnitine transporter 2;Short=CT2;Full=Fly-like putative transporter 2;Short=FLIPT2;Short=Flipt 2;Full=Organic cation transporter OKB1;Full=Organic cation/carnitine transporter 6; Length: 577 a.a., Mass: 64614 Da,
fasta formatted sequence
Function: High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent
Cellular location: Membrane; Multi-pass membrane protein (Potential). Cell membrane. Note=Detected in the plasma mebrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis
Tissue specificity: Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymis (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in hematopoietic cells, including CD34(+) leukocytes and leukemia cells. Abundantly expressed in ovarian cancer clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase

Database cross-references

UniProt: Q86VW1
NextBio: 75982
OMIM: 608276
Ensembl: ENST00000451557
GeneCard: GC06M110424
TCDB: 2.A.1.19.12
PharmGenUCSF: SLC22A16
Guide to Pharmacology: SLC22A16 (1024)
Organic zwitterions/cation transporters (OCTN) (1024)
HGNC: HGNC:20302

Genetic variants

See also Ensembl:ENST00000451557