Protein name: URAT1 Aliases: RST, OAT4L Substrates: urate, organic anions Transport type: Exchanger / organic anions Tissue and cellular expression: kidney Subcellular expression: N/D Disease: renal hypo-uricemia, gout Locus: 11q13.1 Sequence ID: NP_653186.2, NM_144585.2 Gene ID: 116085 Splice variants: 2 splice variants

S22AC_HUMAN (UniProt)

Gene names: SLC22A12, OATL4, URAT1, UNQ6453/PRO34004
Protein names and data: S22AC_HUMAN, Full=Solute carrier family 22 member 12, Full=Organic anion transporter 4-like protein;Full=Renal-specific transporter;Short=RST;Full=Urate anion exchanger 1; Length: 553 a.a., Mass: 59630 Da,
fasta formatted sequence

Function: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions
Cellular location: Cell membrane; Multi-pass membrane protein. Note=Detected in the luminal membrane of the epithelium of renal proximal tubules
Tissue specificity: Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in epithelial cells of proximal tubules in renal cortex

Database cross-references

UniProt: Q96S37
NextBio: 79751
OMIM: 220150 607096
Ensembl: ENST00000377574
GeneCard: GC11P064609
TCDB: 2.A.1.19.11
PharmGenUCSF: SLC22A12
Guide to Pharmacology: SLC22A12 (1031)
Urate transporter (1031)

HGNC: HGNC:17989

Genetic variants

See also Ensembl:ENST00000377574