Protein name: ASCT2, AAAT Aliases: System ASC Substrates: L-Ala, L-Ser, L-Cys, L-Thr, L-Gln, L-Asn Transport type: Cotransporter / Na+, E / amino acids Tissue and cellular expression: lung, skeletal muscle, large intestine, kidney, testis, adipose tissue Subcellular expression: N/D Disease: N/D Locus: 19q13.3 Sequence ID: NP_005619.1, NM_005628.2 Gene ID: 6510 Splice variants: 3 splice variants differ in their 5' UTR, coding sequences, N-terminus


Gene names: SLC1A5, ASCT2, M7V1, RDR, RDRC
Protein names and data: AAAT_HUMAN, Full=Neutral amino acid transporter B(0);Short=ATB(0), Full=Baboon M7 virus receptor;Full=RD114/simian type D retrovirus receptor;Full=Sodium-dependent neutral amino acid transporter type 2;Full=Solute carrier family 1 member 5; Length: 541 a.a., Mass: 56598 Da,
fasta formatted sequence

Function: Has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses
Cellular location: Membrane; Multi-pass membrane protein (Probable). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Tissue specificity: Placenta, lung, skeletal muscle, kidney, pancreas, and intestine

Database cross-references

UniProt: Q15758
NextBio: 25315
OMIM: 109190
Ensembl: ENST00000542575
GeneCard: GC19M046760
TCDB: 2.A.23.3.3
PharmGenUCSF: SLC1A5
Guide to Pharmacology: SLC1A5 (874)
Alanine/serine/cysteine transporter subfamily (874)

HGNC: HGNC:10943

Genetic variants

See also Ensembl:ENST00000542575