Protein name: GLAST, EAAT1 Aliases: System X-AG Substrates: L-Glu, D/L-Asp Transport type: Cotransporter / Na+, H+, K+ Tissue and cellular expression: brain (astrocytes, Bergmann glia), heart, skeletal muscle, placenta Subcellular expression: N/D Disease: Alzheimer's disease, Huntington's disease, epilepsy, cerebellar ataxia type 7, schizophrenia Locus: 5p13 Sequence ID: NP_001160167.1, NP_004163.3, NM_004172.4 Gene ID: 6507 Splice variants: 3 splice variants differ in their 3' UTR, coding sequences, C-terminus

EAA1_HUMAN (UniProt)

Gene names: SLC1A3, EAAT1, GLAST, GLAST1
Protein names and data: EAA1_HUMAN, Full=Excitatory amino acid transporter 1, Full=Sodium-dependent glutamate/aspartate transporter 1;Short=GLAST-1;Full=Solute carrier family 1 member 3; Length: 542 a.a., Mass: 59572 Da,
fasta formatted sequence

Function: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia

Database cross-references

UniProt: P43003
NextBio: 25301
OMIM: 600111 612656
Ensembl: ENST00000381918
GeneCard: GC05P036606
PharmGenUCSF: SLC1A3
Guide to Pharmacology: SLC1A3 (868)
Glutamate transporter subfamily (868)

HGNC: HGNC:10941

Genetic variants

See also Ensembl:ENST00000381918