Protein name: GLT-1, EAAT2 Aliases: System X-AG Substrates: L-Glu, D/L-Asp Transport type: Cotransporter / Na+, H+, K+ Tissue and cellular expression: brain (astrocytes, Bergmann glia, neurons), liver, pancreas Subcellular expression: N/D Disease: amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, epilepsy, ischemia, schizophrenia Locus: 11p13-p12 Sequence ID: NP_001182657.1, NM_001195728.2 NP_001239581.1, NM_001252652.1 NP_004162.2, NM_004171.3 Gene ID: 6506 Splice variants: 3 splice variants differ in their C-terminus

EAA2_HUMAN (UniProt)

Gene names: SLC1A2, EAAT2, GLT1
Protein names and data: EAA2_HUMAN, Full=Excitatory amino acid transporter 2, Full=Glutamate/aspartate transporter II;Full=Sodium-dependent glutamate/aspartate transporter 2;Full=Solute carrier family 1 member 2; Length: 574 a.a., Mass: 62104 Da,
fasta formatted sequence

Function: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium
Cellular location: Membrane; Multi-pass membrane protein

Database cross-references

UniProt: P43004
NextBio: 25297
OMIM: 600300
Ensembl: ENST00000395753
GeneCard: GC11M035272
PharmGenUCSF: SLC1A2
Guide to Pharmacology: SLC1A2 (869)
Glutamate transporter subfamily (869)

HGNC: HGNC:10940

Genetic variants

See also Ensembl:ENST00000395753