Protein name: EAAC1, EAAT3 Aliases: System X-AG Substrates: L-Glu, D/L-Asp Transport type: Cotransporter / Na+, H+, K+ Tissue and cellular expression: brain (neurons), intestine, kidney, liver, heart, placenta Subcellular expression: N/D Disease: Huntington's disease, epilepsy, ischemia, Alzheimer's disease, Niemann-Pick disease, obsessive-compulsive disorder Locus: 9p24 Sequence ID: NP_004161.4, NM_004170.5 Gene ID: 6505 Splice variants: N/D

EAA3_HUMAN (UniProt)

Gene names: SLC1A1, EAAC1, EAAT3
Protein names and data: EAA3_HUMAN, Full=Excitatory amino acid transporter 3, Full=Excitatory amino-acid carrier 1;Full=Neuronal and epithelial glutamate transporter;Full=Sodium-dependent glutamate/aspartate transporter 3;Full=Solute carrier family 1 member 1; Length: 524 a.a., Mass: 57100 Da,
fasta formatted sequence

Function: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity)
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers)

Database cross-references

UniProt: P43005
NextBio: 25293
OMIM: 133550
Ensembl: ENST00000262352
GeneCard: GC09P004490
TCDB: 2.A.23.2.3
PharmGenUCSF: SLC1A1
Guide to Pharmacology: SLC1A1 (870)
Glutamate transporter subfamily (870)

HGNC: HGNC:10939

Genetic variants

See also Ensembl:ENST00000262352