Protein name: THTR2 Aliases: ThTr2 Substrates: thiamine Transport type: Facilitated transporter Tissue and cellular expression: ubiquitous Subcellular expression: Plasma membrane; apical membrane small intestine - role in intestinal thiamine absorption Disease: Thiamine and biotin responsive subacute encephalopathy [OMIM: 607483] Locus: 2q37 Sequence ID: NP_079519.1, NM_025243.3 Gene ID: 80704 Splice variants: N/D

S19A3_HUMAN (UniProt)

Gene names: SLC19A3
Protein names and data: S19A3_HUMAN, Full=Thiamine transporter 2;Short=ThTr-2;Short=ThTr2, Full=Solute carrier family 19 member 3; Length: 496 a.a., Mass: 55665 Da,
fasta formatted sequence

Function: Mediates high affinity thiamine uptake, propably via a proton anti-port mechanism. Has no folate transport activity
Cellular location: Membrane; Multi-pass membrane protein (Potential)
Tissue specificity: Widely expressed but most abundant in placenta, kidney and liver

Database cross-references

UniProt: Q9BZV2
NextBio: 70999
OMIM: 606152 607483
Ensembl: ENST00000425817
GeneCard: GC02M227685
PharmGenUCSF: SLC19A3
Guide to Pharmacology: SLC19A3 (1016)
SLC19 family of vitamin transporters (1016)

HGNC: HGNC:16266

Genetic variants

See also Ensembl:ENST00000425817