Protein name: RFC Aliases: RFC1, RFT Substrates: reduced folates, antifolates Transport type: Exchanger / organic phosphates Tissue and cellular expression: ubiquitous Subcellular expression: plasma membrane Disease: Loss of function results in resistance to methotrexate Locus: 21q22.3 Sequence ID: NP_001192135.1, NM_001205206.1 NP_001192136.1, NM_001205207.1 NP_919231.1, NM_194255.2 Gene ID: 6573 Splice variants: N/D

S19A1_HUMAN (UniProt)

Gene names: SLC19A1, FLOT1, RFC1
Protein names and data: S19A1_HUMAN, Full=Folate transporter 1;Short=FOLT, Full=Intestinal folate carrier 1;Short=IFC-1;Full=Placental folate transporter;Full=Reduced folate carrier protein;Short=RFC;Full=Solute carrier family 19 member 1; Length: 591 a.a., Mass: 64868 Da,
fasta formatted sequence

Function: Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Placenta, liver, and to a much smaller extent, in lung

Database cross-references

UniProt: P41440
NextBio: 25575
OMIM: 600424
Ensembl: ENST00000485649
GeneCard: GC21M045493
TCDB: 2.A.48.1.2
PharmGenUCSF: SLC19A1
Guide to Pharmacology: SLC19A1 (1014)
SLC19 family of vitamin transporters (1014)

HGNC: HGNC:10937

Genetic variants

See also Ensembl:ENST00000485649