Protein name: VMAT2 Aliases: SVAT, SVMT, VAT2, MAT Substrates: 5-HT, DA, NE, epinephrine, histamine Transport type: Exchanger / H+ Tissue and cellular expression: all CNS aminergic neurons, mast cells, platelets, some GI neurons, adrenal medulla Subcellular expression: LDCVs, synaptic vesicles Disease: (unclear) Locus: 10q25 Sequence ID: NP_003045.2, NM_003054.4 Gene ID: 6571 Splice variants: N/D


Gene names: SLC18A2, SVMT, VMAT2
Protein names and data: VMAT2_HUMAN, Full=Synaptic vesicular amine transporter, Full=Monoamine transporter;Full=Solute carrier family 18 member 2;Full=Vesicular amine transporter 2;Short=VAT2; Length: 514 a.a., Mass: 55713 Da,
fasta formatted sequence

Function: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis
Cellular location: Cytoplasmic vesicle membrane; Multi-pass membrane protein

Database cross-references

UniProt: Q05940
NextBio: 25567
OMIM: 193001
Ensembl: ENST00000298472
GeneCard: GC10P117241
TCDB: 2.A.1.2.29
PharmGenUCSF: SLC18A2
Guide to Pharmacology: SLC18A2 (1012)
SLC18 family of vesicular amine transporters (1012)

HGNC: HGNC:10935

Genetic variants

See also Ensembl:ENST00000298472