Protein name: MCT8 Aliases: MOT8, XPCT, MCT7 Substrates: T2, rT3, T3, T4 Transport type: Facilitated transporter Tissue and cellular expression: most tissues including liver, heart, brain, thymus, intestine, ovary, prostate, pancreas, placenta, lung kidney, skeletal muscle Subcellular expression: N/D Disease: Allan-Herndon-Dudley syndrome Locus: Xq13.2, Sequence ID: NP_006508.2, NM_006517.4 Gene ID: 6567 Splice variants: N/D

MOT8_HUMAN (UniProt)

Gene names: SLC16A2, MCT8, XPCT
Protein names and data: MOT8_HUMAN, Full=Monocarboxylate transporter 8;Short=MCT 8, Full=Monocarboxylate transporter 7;Short=MCT 7;Full=Solute carrier family 16 member 2;Full=X-linked PEST-containing transporter; Length: 539 a.a., Mass: 59511 Da,
fasta formatted sequence

Function: Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr (By similarity)
Cellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Tissue specificity: Highly expressed in liver and heart

Database cross-references

UniProt: P36021
NextBio: 25551
OMIM: 300095 300523
Ensembl: ENST00000276033
GeneCard: GC0XP074423
PharmGenUCSF: SLC16A2
Guide to Pharmacology: SLC16A2 (992)
SLC16 family of monocarboxylate transporters (992)

HGNC: HGNC:10923

Genetic variants

See also Ensembl:ENST00000276033