Protein name: PHT1 Aliases: peptide/histidine transporter 1, PTR4 Substrates: di- and tri-peptides, protons, histidine Transport type: Cotransporter / H+ Tissue and cellular expression: brain, eye, intestine (faintly in lung and spleen) Subcellular expression: N/D Disease: inflammatory bowel disease (colonic upregulation) Locus: 12q24.32 Sequence ID: NP_663623.1, NM_145648.3 Gene ID: 121260 Splice variants: N/D

S15A4_HUMAN (UniProt)

Gene names: SLC15A4, PHT1, PTR4, FP12591
Protein names and data: S15A4_HUMAN, Full=Solute carrier family 15 member 4, Full=Peptide transporter 4;Full=Peptide/histidine transporter 1;Short=hPHT1; Length: 577 a.a., Mass: 62034 Da,
fasta formatted sequence

Function: Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides
Cellular location: Membrane; Multi-pass membrane protein (Potential)
Tissue specificity: Highly expressed in skeletal muscle. Moderately expressed in kidney, liver, and heart. Weakly expressed in colon and brain. Expressed in low levels throughout the gastrointestinal tract and in Caco-2 cells. Expressed in retinal fragment epithelium (RPE) and neural retina. Expressed in small intestine, stomach, duodenum, jejunum, ileum and colon

Database cross-references

UniProt: Q8N697
NextBio: 80688
Ensembl: ENST00000544112
GeneCard: GC12M128793
PharmGenUCSF: SLC15A4
Guide to Pharmacology: SLC15A4 (987)
SLC15 family of peptide transporters (987)

HGNC: HGNC:23090

Genetic variants

See also Ensembl:ENST00000544112