Protein name: PEPT1 Aliases: oligopeptide transporter 1, H+-peptide transporter 1 Substrates: di- and tri-peptides, protons, beta-lactam antibiotics Transport type: Cotransporter / H+ Tissue and cellular expression: small intestine, kidney, pancreas, bile duct, liver Subcellular expression: apical surface of epithelial cells from small intestine and kidney Disease: inflammatory bowel disease (Ser117Asn SNP, colonic upregulation) Locus: 13q32.3 Sequence ID: NP_005064.1, NM_005073.3 Gene ID: 6564 Splice variants: N/D

S15A1_HUMAN (UniProt)

Gene names: SLC15A1, PEPT1
Protein names and data: S15A1_HUMAN, Full=Solute carrier family 15 member 1, Full=Intestinal H(+)/peptide cotransporter;Full=Oligopeptide transporter, small intestine isoform;Full=Peptide transporter 1; Length: 708 a.a., Mass: 78806 Da,
fasta formatted sequence

Function: Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products
Cellular location: Membrane; Multi-pass membrane protein

Database cross-references

UniProt: P46059
NextBio: 25539
OMIM: 600544
Ensembl: ENST00000376503
GeneCard: GC13M098683
PharmGenUCSF: SLC15A1
Guide to Pharmacology: SLC15A1 (984)
SLC15 family of peptide transporters (984)

HGNC: HGNC:10920

Genetic variants

See also Ensembl:ENST00000376503