Protein name: NaC2 Aliases: NaCT Substrates: citrate, succinate, pyruvate Transport type: Cotransporter / Na+ Tissue and cellular expression: liver, brain, testis Subcellular expression: N/D Disease: none Locus: 17p13 Sequence ID: NP_001137310.1, NM_001143838.1 NP_808218.1, NM_177550.3 Gene ID: 284111 Splice variants: one 3.2kb functional transcript, one transcript lacking 43 N-terminal residues (function unknown)

S13A5_HUMAN (UniProt)

Gene names: SLC13A5, NACT
Protein names and data: S13A5_HUMAN, Full=Solute carrier family 13 member 5, Full=Na(+)/citrate cotransporter;Short=NaCT;Full=Sodium-coupled citrate transporter;Full=Sodium-dependent citrate transporter; Length: 568 a.a., Mass: 63062 Da,
fasta formatted sequence

Function: High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Expressed most predominantly in the liver, with moderate expression detectable in the brain and testis

Database cross-references

UniProt: Q86YT5
NextBio: 94549
OMIM: 608305
Ensembl: ENST00000573648
GeneCard: GC17M006684
TCDB: 2.A.47.1.9
PharmGenUCSF: SLC13A5
Guide to Pharmacology: SLC13A5 (981)
SLC13 family of sodium-dependent sulphate/carboxylate transporters (981)

HGNC: HGNC:23089

Genetic variants

See also Ensembl:ENST00000573648