Protein name: NaC3 Aliases: NaDC3, NaC3, SDCT2 Substrates: succinate, citrate, ?-ketoglutarate, NALA, glutarate and its derivatives Transport type: Cotransporter / Na+ Tissue and cellular expression: kidney, proximal tubule, liver, pancreas, brain, placenta Subcellular expression: basolateral membrane (kidney) Disease: possible indirect role in glutaric aciduria type 1, Canavan disease, Locus: 20q13.12 Sequence ID: NP_001011554.1, NM_001011554.2 NP_001180269.1, NM_001193340.1 NP_073740.2, NM_022829.5 Gene ID: 64849 Splice variants: one 3.6kb transcript only

S13A3_HUMAN (UniProt)

Gene names: SLC13A3, NADC3, SDCT2
Protein names and data: S13A3_HUMAN, Full=Solute carrier family 13 member 3, Full=Na(+)/dicarboxylate cotransporter 3;Short=NaDC-3;Short=hNaDC3;Full=Sodium-dependent high-affinity dicarboxylate transporter 2; Length: 602 a.a., Mass: 66841 Da,
fasta formatted sequence

Function: High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na(+) for 1 divalent succinate
Cellular location: Cell membrane; Multi-pass membrane protein
Tissue specificity: Expression is highest in kidney. Detected in placenta, brain, liver and pancreas

Database cross-references

UniProt: Q8WWT9
NextBio: 66966
OMIM: 606411
Ensembl: ENST00000472148
GeneCard: GC20M046557
PharmGenUCSF: SLC13A3
Guide to Pharmacology: SLC13A3 (979)
SLC13 family of sodium-dependent sulphate/carboxylate transporters (979)

HGNC: HGNC:14430

Genetic variants

See also Ensembl:ENST00000472148