Protein name: KCC4 Aliases: N/D Substrates: K+, Cl- Transport type: N/D Tissue and cellular expression: extensive, limited in brain Subcellular expression: N/D Disease: N/D Locus: 5p15 Sequence ID: NP_006589.2, NM_006598.2 Gene ID: 10723 Splice variants: N/D

S12A7_HUMAN (UniProt)

Gene names: SLC12A7, KCC4
Protein names and data: S12A7_HUMAN, Full=Solute carrier family 12 member 7, Full=Electroneutral potassium-chloride cotransporter 4;Full=K-Cl cotransporter 4; Length: 1083 a.a., Mass: 119106 Da,
fasta formatted sequence

Function: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity)
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Detected in muscle, brain, lung, heart and kidney

Database cross-references

UniProt: Q9Y666
NextBio: 40705
OMIM: 604879
Ensembl: ENST00000264930
GeneCard: GC05M001050
PharmGenUCSF: SLC12A7
Guide to Pharmacology: SLC12A7 (974)
SLC12 family of cation-coupled chloride transporters (974)

HGNC: HGNC:10915

Genetic variants

See also Ensembl:ENST00000264930