Protein name: KCC2 Aliases: N/D Substrates: K+, Cl- Transport type: N/D Tissue and cellular expression: neurons Subcellular expression: N/D Disease: N/D Locus: 20q13 Sequence ID: NP_001128243.1, NM_001134771.1 NP_065759.1, NM_020708.4 Gene ID: 57468 Splice variants: N/D

S12A5_HUMAN (UniProt)

Gene names: SLC12A5, KCC2, KIAA1176
Protein names and data: S12A5_HUMAN, Full=Solute carrier family 12 member 5, Full=Electroneutral potassium-chloride cotransporter 2;Full=K-Cl cotransporter 2;Short=hKCC2;Full=Neuronal K-Cl cotransporter; Length: 1139 a.a., Mass: 126184 Da,
fasta formatted sequence

Function: Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Brain specific. Detected in neuronal cells

Database cross-references

UniProt: Q9H2X9
NextBio: 63686
OMIM: 606726
Ensembl: ENST00000454036
GeneCard: GC20P046021
PharmGenUCSF: SLC12A5
Guide to Pharmacology: SLC12A5 (972)
SLC12 family of cation-coupled chloride transporters (972)

HGNC: HGNC:13818

Genetic variants

See also Ensembl:ENST00000454036