Protein name: NCC Aliases: N/D Substrates: Na+, Cl- Transport type: N/D Tissue and cellular expression: kidney, bone Subcellular expression: N/D Disease: Gitelman syndrome Locus: 16q13 Sequence ID: NP_000330.2, NM_000339.2 NP_001119579.1, NM_001126107.1 NP_001119580.1, NM_001126108.1 Gene ID: 6559 Splice variants: N/D

S12A3_HUMAN (UniProt)

Gene names: SLC12A3, TSC
Protein names and data: S12A3_HUMAN, Full=Solute carrier family 12 member 3, Full=Na-Cl cotransporter;Short=NCC;Full=Na-Cl symporter;Full=Thiazide-sensitive sodium-chloride cotransporter; Length: 1021 a.a., Mass: 113139 Da,
fasta formatted sequence

Function: Key mediator of sodium and chloride reabsorption in this nephron segment, accounting for a significant fraction of renal sodium reabsorption
Cellular location: Cell membrane; Multi-pass membrane protein
Tissue specificity: Predominant in kidney

Database cross-references

UniProt: P55017
NextBio: 25523
OMIM: 263800 600968
Ensembl: ENST00000566786
GeneCard: GC16P056899
TCDB: 2.A.30.4.2
PharmGenUCSF: SLC12A3
Guide to Pharmacology: SLC12A3 (970)
SLC12 family of cation-coupled chloride transporters (970)

HGNC: HGNC:10912

Genetic variants

See also Ensembl:ENST00000566786