Protein name: DMT1 Aliases: NRAMP2, DCT1 Substrates: Fe2+, Cd2+, Co2+, Cu1+, Mn2+, Ni2+, Pb2+, Zn2+ Transport type: Cotransporter / H+ Tissue and cellular expression: widespread, including intestine (duodenum), erythroid cells, kidney, lung, brain, testis (Sertoli cells), thymus Subcellular expression: N/D Disease: hypochromic microcytic anemia, Parkinson?s disease, esophageal, colorectal cancer Locus: 12q13 Sequence ID: NP_000608.1, NM_000617.2 NP_001167596.1, NM_001174125.1 NP_001167597.1, NM_001174126.1 NP_001167598.1, NM_001174127.1 NP_001167599.1, NM_001174128.1 NP_001167600.1, NM_001174129.1 Gene ID: 4891 Splice variants: multiple splice forms, from 1A or 1B exons at 5_ end, with or without 3_ iron-responsive element


Gene names: SLC11A2, DCT1, DMT1, NRAMP2, OK/SW-cl.20
Protein names and data: NRAM2_HUMAN, Full=Natural resistance-associated macrophage protein 2;Short=NRAMP 2, Full=Divalent cation transporter 1;Full=Divalent metal transporter 1;Short=DMT-1; Length: 568 a.a., Mass: 62266 Da,
fasta formatted sequence

Function: Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution
Cellular location: Endosome membrane; Multi-pass membrane protein
Tissue specificity: Ubiquitously expressed. Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in spleen, thymus and pancreas. Isoform 3 and isoform 4 are abundantly expressed in duodenum and kidney

Database cross-references

UniProt: P49281
NextBio: 18825
OMIM: 206100 600523
Ensembl: ENST00000547688
GeneCard: GC12M050979
TCDB: 2.A.55.2.1
PharmGenUCSF: SLC11A2
Guide to Pharmacology: SLC11A2 (967)
SLC11 family of proton-coupled metal ion transporters (967)

HGNC: HGNC:10908

Genetic variants

See also Ensembl:ENST00000547688