SLC38A2

Protein name: SNAT2 Aliases: ATA2, SAT2 Substrates: A, N, C, Q, G, H, M, P, S Transport type: Cotransporter / Na+ Tissue and cellular expression: ubiquitous Subcellular expression: N/D Disease: N/D Locus: 12q13.11 Sequence ID: NP_061849.2, NM_018976.4 Gene ID: 54407 Splice variants: N/D

S38A2_HUMAN (UniProt)

Gene names: SLC38A2, ATA2, KIAA1382, SAT2, SNAT2
Protein names and data: S38A2_HUMAN, Full=Sodium-coupled neutral amino acid transporter 2, Full=Amino acid transporter A2;Full=Protein 40-9-1;Full=Solute carrier family 38 member 2;Full=System A amino acid transporter 2;Full=System A transporter 1;Full=System N amino acid transporter 2; Length: 506 a.a., Mass: 56026 Da,
fasta formatted sequence
Function: Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta
Cellular location: Cell membrane; Multi-pass membrane protein. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal
Tissue specificity: Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level)

Database cross-references

UniProt: Q96QD8
NextBio: 56613
OMIM: 605180
Ensembl: ENST00000256689
GeneCard: GC12M046358
TCDB: 2.A.18.6.5
PharmGenUCSF: SLC38A2
Guide to Pharmacology: SLC38A2 (1170)
System A-like transporters (1170)
HGNC: HGNC:13448

Genetic variants

See also Ensembl:ENST00000256689