SLC30A5
Protein name: N/D Aliases: ZnT5 Substrates: N/D Transport type: N/D Tissue and cellular expression: widespread, predominant in heart, placenta, pancreas, prostate, ovary, testis, small intestine, thymus, bone Subcellular expression: Golgi, unknown vesicles (isoform a) plasma membrane (isoform b) Disease: bone abnormalities, heart failure Locus: N/D Sequence ID: NP_001238898.1, NM_001251969.1 NP_075053.2, NM_022902.4 NP_076960.1, NM_024055.4 Gene ID: 64924 Splice variants: N/DZNT5_HUMAN (UniProt)
Gene names: SLC30A5, ZNT5, ZNTL1, ZTL1, UNQ863/PRO1879Protein names and data: ZNT5_HUMAN, Full=Zinc transporter 5;Short=ZnT-5, Full=Solute carrier family 30 member 5;Full=ZnT-like transporter 1;Short=hZTL1; Length: 765 a.a., Mass: 84047 Da,
fasta formatted sequence
Function: Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP
Cellular location: Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles
Tissue specificity: Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly in insulin- containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells
Database cross-references
UniProt: Q8TAD4NextBio: 67071
OMIM: 607819
Ensembl: ENST00000396591
GeneCard: GC05P069093
TCDB: 2.A.4.4.3
PharmGenUCSF: SLC30A5
Guide to Pharmacology: SLC30A5 (1125)
SLC30 zinc transporter family (1125)
HGNC: HGNC:19089
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