SLC22A8

Protein name: OAT3 Aliases: N/D Substrates: organic anions Transport type: Exchanger / dicarboxylate Tissue and cellular expression: kidney, brain, skeletal muscle, developing bone Subcellular expression: basolateral membrane of proximal tubules (kidney), luminal membrane of choroid plexus (brain) Disease: N/D Locus: 11q11 Sequence ID: NP_001171661.1, NM_001184732.1 NP_001171662.1, NM_001184733.1 NP_001171665.1, NM_001184736.1 NP_004245.2, NM_004254.3 Gene ID: 9376 Splice variants: N/D

S22A8_HUMAN (UniProt)

Gene names: SLC22A8, OAT3
Protein names and data: S22A8_HUMAN, Full=Solute carrier family 22 member 8, Full=Organic anion transporter 3;Short=hOAT3; Length: 542 a.a., Mass: 59856 Da,
fasta formatted sequence
Function: Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA)
Cellular location: Basolateral cell membrane; Multi-pass membrane protein (Potential). Note=Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity)
Tissue specificity: Expressed in kidney

Database cross-references

UniProt: Q8TCC7
NextBio: 35126
OMIM: 607581
Ensembl: ENST00000430500
GeneCard: GC11M063012
PharmGenUCSF: SLC22A8
Guide to Pharmacology: SLC22A8 (1027)
Organic anion transporters (OATs) (1027)
HGNC: HGNC:10972

Genetic variants

See also Ensembl:ENST00000430500